full transcript
From the Ted Talk by Matt Langione: The promise of quantum computers
Unscramble the Blue Letters
For another example, let's return to drug discovery, a process COVID-19 has brought into sharp fcous for most of us for the very first time. Designing a vcinace for an infectious disease like COVID-19, from identifying the drivers of the deaisse, to screening millions of candidate activators and inhibitors, is a process that tyalcilpy tekas 10 or more years per drug, 90 percent of which fail to pass clinical trials. The cost to pharmaceutical cpmieanos is two to three biloiln dollars per approved drug. But the social costs of dyaels and failures are much, much heghir. More than eight million people die every year of infectious diseases. That's 15 times as many people as died during the first six months of the coioanrurvs pandemic. So why has computational drug design failed to live up to etitoexcpans? Again, it's a matter of limited computational resources, at least in part. If identifying a disease pathway in the body is like a lock, dngiseing a drug ruqeeris searching through a massive chemical space, effectively a maze of molecular structures, to find the right compound, to find a key, in other words, that fits the lock. The pleborm is that tracing the entire rlevneat span of chemical space and converting it into a searchable dsaabtae for drug design would take 5 trillion trillion, trillion, tllrioin years on the world's fastest supercomputer. On a quantum computer, a little more than a half hour.
Open Cloze
For another example, let's return to drug discovery, a process COVID-19 has brought into sharp _____ for most of us for the very first time. Designing a _______ for an infectious disease like COVID-19, from identifying the drivers of the _______, to screening millions of candidate activators and inhibitors, is a process that _________ _____ 10 or more years per drug, 90 percent of which fail to pass clinical trials. The cost to pharmaceutical _________ is two to three _______ dollars per approved drug. But the social costs of ______ and failures are much, much ______. More than eight million people die every year of infectious diseases. That's 15 times as many people as died during the first six months of the ___________ pandemic. So why has computational drug design failed to live up to ____________? Again, it's a matter of limited computational resources, at least in part. If identifying a disease pathway in the body is like a lock, _________ a drug ________ searching through a massive chemical space, effectively a maze of molecular structures, to find the right compound, to find a key, in other words, that fits the lock. The _______ is that tracing the entire ________ span of chemical space and converting it into a searchable ________ for drug design would take 5 trillion trillion, trillion, ________ years on the world's fastest supercomputer. On a quantum computer, a little more than a half hour.
Solution
- vaccine
- coronavirus
- requires
- delays
- focus
- expectations
- trillion
- billion
- companies
- disease
- typically
- database
- higher
- takes
- relevant
- designing
- problem
Original Text
For another example, let's return to drug discovery, a process COVID-19 has brought into sharp focus for most of us for the very first time. Designing a vaccine for an infectious disease like COVID-19, from identifying the drivers of the disease, to screening millions of candidate activators and inhibitors, is a process that typically takes 10 or more years per drug, 90 percent of which fail to pass clinical trials. The cost to pharmaceutical companies is two to three billion dollars per approved drug. But the social costs of delays and failures are much, much higher. More than eight million people die every year of infectious diseases. That's 15 times as many people as died during the first six months of the coronavirus pandemic. So why has computational drug design failed to live up to expectations? Again, it's a matter of limited computational resources, at least in part. If identifying a disease pathway in the body is like a lock, designing a drug requires searching through a massive chemical space, effectively a maze of molecular structures, to find the right compound, to find a key, in other words, that fits the lock. The problem is that tracing the entire relevant span of chemical space and converting it into a searchable database for drug design would take 5 trillion trillion, trillion, trillion years on the world's fastest supercomputer. On a quantum computer, a little more than a half hour.
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Important Words
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